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A small, friendly reminder:

Injectable hormones are suspended in ~~castor oil~~ a carrier oil. ~~Castor oil~~ Carrier oils are really good at keeping those hormones dissolved.

But ~~castor oil~~ carrier oils go rancid over the course of a few years, depending on what type they are. Faster if you don't keep it in a dark place. And rancid ~~castor oil~~ carrier oils don't work properly, and can even hurt you.

So, please keep an eye on the expiration date of any vial of hormones you have or get, and discard anything past its expiration date promptly.

Because you can't tell if ~~castor oil~~ carrier oils have gone rancid by sight. Only smell or texture.

And you can't smell or feel it in a sealed vial.

Edit: I was not entirely correct here--injectable hormones use a variety of oils, some of which are longer-lived than castor.

That being said, the core point remains: Please take the expiration dates on your injectable hormones seriously, especially if you have other comorbidities that can interact with injections.

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Als Antwort auf Doc Impossible

- If I remember

Estradiol valerate uses castor oil, (sometimes sesame oil)

Estradiol cypionate uses cottonseed oil.

That being said, they both have roughly 12-24 months and really like a cool dark place.

Als Antwort auf Doc Impossible

- I doublechecked the formulary, and I can't find castor oil in cyp. (and one of the reasons I was given for why cyp takes longer to break down is because it's not castor).
Als Antwort auf Shannon McKinnion

mmmm from the data sheets I can find, cottonseed oil goes rancid *faster* that castor, not slower. Max tested life before rancidity was just under 650 days, from the Science Direct source I found.

I'd love a source that says otherwise.

EDIT: Someone found information showing otherwise. Please disregard this!

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Als Antwort auf Doc Impossible

- So would I. I've been using the 12-24 month as a baseline for my stockpile, but if it's lower, I'm going to want to refigure out things.
Als Antwort auf Shannon McKinnion

@shannon_mck I can't find a definitive statement on Pfizer EC. This is their MSDS, and it doesn't address it.

Mind checking the expiry on your vials? The suggestions I've been able to find (poor source strength) says they dare them for 6-12 months from manufacture (and, if so, the shorter shelf life would explain why there seem to be shortages of EC so much more often than EV).

pfe-pfizercom-prod.s3.amazonaw…

Als Antwort auf Doc Impossible

- I will do that! (I'm in the lab right now, saying Very Bad Words to ArcGIS)
Als Antwort auf Doc Impossible

- So I checked. (because I said I would)

Of the six vials of cyp I have (5 mg/ml, inject 0.5ml a week), Two expire 11/2027 and four expire 6/2029

The two vials of val I got (my doctor wanted me to have backups in case the cyp got in short supply again, 100 mg/ml, inject 1 ml a week), both expire 7/2026.

So it seems like, provided storage is good, it makes more sense to use the val first and the cyp second. :)

Now, if I could get my hands on more progesterone.... :)

Als Antwort auf Doc Impossible

can't even be sure that's an issue with how low-concentration cypionate is anyway, difficult to build a reserve when one only gets maybe a single extra dose from a vial

am curious about diy suppliers who just specify 'mct' though

Als Antwort auf Raeve

@raeve @shannon_mck the issue isn't the concentration, it's the carrier oil going rancid. Once chemical compounds change, all sort of things go up in the air, and the needle moves from "safe" to "not safe."

Note: this doesn't mean "unsafe." it's that nebulous, risky never-never land.

Als Antwort auf Doc Impossible

yeah I'm just speaking to whether a vial of US cypionate could even reach that point, as the doses-per-vial doesn't have any excess

... which is largely why I switched to valerate and the expiration actually becomes a concern ​:ablobcatcoffee:

Als Antwort auf Raeve

@raeve @shannon_mck update: someone elsewhere found safety data that says otherwise, so please disregard what I Siad about cottonseed oil!
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Doc Impossible

@old_angry_queer Nope! The benzyl alcohol is an antimicrobial. It's there to keep the tiny number of microbes that get into the vial when you pierce it from proliferating.

Rancidity happens even in a completely anaerobic environment, and is fundamentally a factor of time and entropy (aided by other things for sure).

Als Antwort auf Doc Impossible

does refrigeration/freezing impact the vials? I was thinking about cold storage for long term on what I have if need be
Als Antwort auf Doc Impossible

Yeah, that makes some things more complicated, and that's all I'll say.
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Doc Impossible
@liferstate longer than castor oil, apparently.